Chemistry:AM-919
From HandWiki
Short description: Chemical compound
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| Formula | C27H44O4 |
| Molar mass | 432.645 g·mol−1 |
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AM-919 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxypropyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-919 represents a hybrid structure between the classical dibenzopyran and nonclassical cannabinoid families.[1]
AM-919 is somewhat less potent than HU-210 itself, but is still a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 2.2 nM at CB1 and 3.4 nM at CB2.[2][3]
See also
References
- ↑ Pertwee, Roger. Cannabinoids. Handbook of Experimental Pharmacology. 168. Springer. p. 269. ISBN 3-540-22565-X.
- ↑ "Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain". Life Sciences 56 (23–24): 2007–12. 1995. doi:10.1016/0024-3205(95)00182-6. PMID 7776825.
- ↑ "Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues". Journal of Medicinal Chemistry 41 (19): 3596–608. September 1998. doi:10.1021/jm960677q. PMID 9733485.
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