Chemistry:RCS-8

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Short description: Chemical compound
RCS-8
RCS-8.svg
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC25H29NO2
Molar mass375.512 g·mol−1
3D model (JSmol)
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RCS-8 (also known as 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole, SR-18, and BTM-8) is a synthetic cannabinoid that has been found as an ingredient of "herbal" synthetic cannabis blends. It can be described as an analogue of JWH-250 with the 1-pentyl group replaced by 1-(2-cyclohexylethyl), and can be expected to be less potent than JWH-250 (cf. JWH-007 and its cyclohexylethyl analogue).[1] Despite not having been reported in the scientific or patent literature as yet, reputed recreational use of RCS-8 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act, aiming to add a number of synthetic drugs into Schedule I.[2] In addition, all CB1 receptor agonists of the 3-phenylacetylindole class such as RCS-8 are Schedule I Controlled Substances.[3]

See also

References

  1. "Design, Synthesis and Pharmacology of Cannabimimetic Indoles". Bioorganic & Medicinal Chemistry Letters 4 (4): 563–566. 1994. doi:10.1016/S0960-894X(01)80155-4. 
  2. Synthetic Drug Control Act of 2011
  3. 21 U.S.C. § 812: Schedules of controlled substances