Chemistry:AMG-1
From HandWiki
Short description: Chemical compound
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| Formula | C23H30O2 |
| Molar mass | 338.491 g·mol−1 |
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AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6 nM at CB1 vs 3.1 nM at CB2.[1][2]
See also
References
- ↑ "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of Medicinal Chemistry 46 (15): 3221–9. July 2003. doi:10.1021/jm020558c. PMID 12852753.
- ↑ "QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency". Journal of Medicinal Chemistry 43 (1): 59–70. January 2000. doi:10.1021/jm9902281. PMID 10633038.
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