Chemistry:AM-1714
From HandWiki
Short description: Chemical compound
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| Formula | C22H26O4 |
| Molar mass | 354.446 g·mol−1 |
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AM-1714 (part of the AM cannabinoid series) is a drug that acts as a reasonably selective agonist of the peripheral cannabinoid receptor CB2, with sub-nanomolar affinity and 490x selectivity over the related CB1 receptor. In animal studies it has both analgesic and anti-allodynia effects. The 9-methoxy derivative AM-1710 has similar CB2 affinity but only 54x selectivity over CB1.[1][2]
See also
References
- ↑ "Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity". Journal of Medicinal Chemistry 50 (26): 6493–500. December 2007. doi:10.1021/jm070441u. PMID 18038967.
- ↑ "Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats". The Journal of Pharmacology and Experimental Therapeutics 327 (2): 584–91. November 2008. doi:10.1124/jpet.108.141994. PMID 18664590.
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