Chemistry:RCS-4
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| Formula | C21H23NO2 |
| Molar mass | 321.420 g·mol−1 |
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RCS-4, or 1-pentyl-3-(4-methoxybenzoyl)indole, is a synthetic cannabinoid drug sold under the names SR-19, BTM-4, or Eric-4 (later shortened to E-4), but originally, OBT-199.
Pharmacology
RCS-4 is a potent cannabinoid receptor agonist, with EC50 values of 146 nM for human CB1 receptors, and 46 nM for human CB2 receptors.[2] All methoxyphenyl regioisomers, and N-butyl homologues of RCS-4 and its regioisomers also display potent agonist activities at CB1 and CB2 receptors.[2]
Legality
RCS-4 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.[3][4]
It was outlawed in Denmark on 11 March 2011.[5]
In August 2011, New Zealand added not only RCS-4 but also its 1-butyl homologue, and the 2-methoxybenzoyl isomers of both these compounds, to a temporary class drug schedule (i.e. equivalent to Class C but reviewed after 12 months, and with personal possession and use of small amounts decriminalised), which was newly created under the Misuse of Drugs Amendment Act 2011 passed a week earlier.[6][7][8]
As of October 2015 RCS-4 is a controlled substance in China.[9]
See also
References
- ↑ "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )". Internetowy System Aktów Prawnych. http://isap.sejm.gov.pl/DetailsServlet?id=WDU20111050614.
- ↑ 2.0 2.1 "Structure–activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues". Forensic Toxicology 33 (2): 355–366. 2015. doi:10.1007/s11419-015-0282-9. https://zenodo.org/record/47807.
- ↑ Swedish Code of Statutes Regulation (2010:1086).
- ↑ Swedish Code of Statutes Regulation (2010:1086). (pdf)
- ↑ "Bilag 1 - Liste over euforiserende midler omfattet af bekendtgørelsen". Ministeriet for Sundhed og Forebyggelse. http://laegemiddelstyrelsen.dk/~/media/AC4F04EB48F74523A76BA84DAB9B6067.ashx.
- ↑ "Kronic ban passed by Parliament". The New Zealand Herald. NZPA. 4 August 2011. http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10742964.
- ↑ "Synthetic cannabis off shelves by Wednesday". The New Zealand Herald. NZPA. 9 August 2011. http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=10743976.
- ↑ New Zealand Gazette. Tuesday 9 August 2011. Issue No 122, pp 3365-3366. Departmental Notices. Health. Misuse of Drugs Act 1975. Temporary Class Drug Notice.
- ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. http://www.sfda.gov.cn/WS01/CL0056/130753.html.
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