Chemistry:MN-18
From HandWiki
Short description: Chemical compound
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| Formula | C23H23N3O |
| Molar mass | 357.457 g·mol−1 |
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MN 18 is an indazole-based synthetic cannabinoid that is an agonist for the cannabinoid receptors, with Ki values of 45.72 nM at CB1 and 11.098 nM at CB2 and EC50 values of 2.028 nM at CB1 and 1.233 nM at CB2,[1] and has been sold online as a designer drug.[2][3] It is the indazole core analogue of NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 metabolism has been described in literature.[4][5]
Legal status
MN-18 is banned in Sweden.[when?][6] On 15 September 2014 the Turkey government banned the sale of MN-18.[7]
See also
- 5F-NNE1
- 5F-PB-22
- AM-2201
- BB-22
- FUB-JWH-018
- AB-FUBINACA
- ADB-FUBINACA
- AMB-FUBINACA
- FDU-PB-22
- FUB-144
- FUB-APINACA
- FUB-PB-22
- MDMB-FUBICA
- MDMB-FUBINACA
- PB-22
References
- ↑ "Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA". The Journal of Pharmacology and Experimental Therapeutics 365 (2): 437–446. May 2018. doi:10.1124/jpet.117.246983. PMID 29549157. PMC 5932312. http://jpet.aspetjournals.org/content/early/2018/03/16/jpet.117.246983.
- ↑ "MN-18". Southern Association of Forensic Scientists. http://forendex.southernforensic.org/index.php/detail/index/1276.
- ↑ "N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology 33 (2): 244–259. February 2015. doi:10.1007/s11419-015-0268-7. PMID 26257833.
- ↑ "Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18". Clinical Chemistry 63 (11): 1753–1763. November 2017. doi:10.1373/clinchem.2017.277152. PMID 28821542. http://clinchem.aaccjnls.org/content/63/11/1753.long.
- ↑ "Kinetic and metabolic profiles of synthetic cannabinoids NNEI and MN-18". Drug Testing and Analysis 10 (1): 137–147. January 2018. doi:10.1002/dta.2262. PMID 28834241.
- ↑ "Cannabinoider föreslås bli klassificerade som hälsofarlig vara". Folkhälsomyndigheten. 28 May 2014. http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/maj/cannabinoider-foreslas-bli-klassificerade-som-halsofarlig-vara/.
- ↑ "Turkish Drug Law List". Resmi Gazete. 15 Sep 2014. http://www.resmigazete.gov.tr/eskiler/2014/10/20141002-5-1.pdf/.
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