Chemistry:AMG-36
From HandWiki
Short description: Chemical compound
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| Formula | C27H40O2 |
| Molar mass | 396.615 g·mol−1 |
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AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs 1.92 nM at CB2.[1][2]
See also
References
- ↑ "Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'". Journal of Medicinal Chemistry 46 (15): 3221–9. July 2003. doi:10.1021/jm020558c. PMID 12852753.
- ↑ "C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols". Journal of Medicinal Chemistry 50 (17): 4048–60. August 2007. doi:10.1021/jm070121a. PMID 17672444.
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