Chemistry:MMB-2201
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| Formula | C20H27FN2O3 |
| Molar mass | 362.445 g·mol−1 |
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MMB-2201 (also known as MMB-5F-PICA[1], 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB) is a potent indole-3-carboxamide based synthetic cannabinoid,[2] which has been sold as a designer drug and as an active ingredient in synthetic cannabis blends.[3] It was first reported in Russia and Belarus in January 2014, but has since been sold in a number of other countries. In the United States, MMB-2201 was identified in Drug Enforcement Administration drug seizures for the first time in 2018.[4]
MMB-2201 is the indole core analogue of 5F-AMB. Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group with attached isopropyl or tert-butyl substituent, have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to many deaths in Russia, Japan, Europe and the United States.[5][6]
Legality
MMB-2201 is illegal in Russia, Belarus and Sweden.[7]
See also
References
- ↑ Pulver, Benedikt; Fischmann, Svenja; Gallegos, Ana; Christie, Rachel (March 2023). "EMCDDA framework and practical guidance for naming synthetic cannabinoids". Drug Testing and Analysis 15 (3): 255–276. doi:10.1002/dta.3403.
- ↑ "Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues". ACS Chemical Neuroscience 7 (9): 1241–1254. September 2016. doi:10.1021/acschemneuro.6b00137. PMID 27421060.
- ↑ "MMB-2201". Cayman Chemical. https://www.caymanchem.com/app/template/Product.vm/catalog/15971.
- ↑ "Adolescents and Drug Abuse: 21st Century Synthetic Substances". Clinical Pediatric Emergency Medicine 20 (1): 17–24. 2019. doi:10.1016/j.cpem.2019.03.003.
- ↑ "New Synthetic Cannabinoid – Methyl 2-{[1-(5-Fluoro-Pentyl)-3-Methyl-1H -Indol-3-Ylcarbonyl-Amino}Butyrate – as a Designer Drug"]. Chemistry of Heterocyclic Compounds 50 (4): 583–586. July 2014. doi:10.1007/s10593-014-1511-6. https://www.researchgate.net/publication/263853259.
- ↑ "Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group". Analytical and Bioanalytical Chemistry 407 (21): 6301–6315. August 2015. doi:10.1007/s00216-015-8612-7. PMID 25893797.
- ↑ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in sv). Folkhälsomyndigheten. http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/.
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