Chemistry:5F-ADB-PINACA
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Short description: Chemical compound
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| Formula | C19H27FN4O2 |
| Molar mass | 362.449 g·mol−1 |
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5F-ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.24 nM and 2.1 nM respectively.[1][2]
Metabolism
Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.[3]
Legality
5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[4]
See also
- 5F-AB-PINACA
- 5F-ADB
- 5F-AMB
- 5F-APINACA
- AB-FUBINACA
- AB-CHFUPYCA
- AB-CHMINACA
- AB-PINACA
- ADB-CHMINACA
- ADB-FUBINACA
- ADB-PINACA
- ADBICA
- APICA
- APINACA
- APP-FUBINACA
- MDMB-CHMICA
- MDMB-CHMINACA
- MDMB-FUBINACA
- PX-1
- PX-2
- PX-3
References
- ↑ "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience 6 (9): 1546–59. September 2015. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
- ↑ "5F-ADB-PINACA". Cayman Chemical. https://www.caymanchem.com/app/template/Product.vm/catalog/14764.
- ↑ "Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry". Clinical Chemistry 63 (5): 1008–1021. May 2017. doi:10.1373/clinchem.2016.267575. PMID 28302730.
- ↑ "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx.
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