Chemistry:Dynorphin A
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| Other names
Dynorphin 1-13
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PubChem CID
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| Properties | |
| C75H126N24O15 | |
| Molar mass | 1603.95474 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor.[2] Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.
Dynorphin A1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.[3][4] Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;[4] it has the highest binding affinity for the kappa-opioid receptor.[4] Structures of dynorphin A bound to the κ-opioid receptor have been reported.[2][5]
References
- ↑ Dynorphin 1-13 - Compound Summary, PubChem.
- ↑ 2.0 2.1 Wang, Yue; Zhuang, Youwen; DiBerto, Jeffrey F.; Zhou, X. Edward; Schmitz, Gavin P.; Yuan, Qingning; Jain, Manish K.; Liu, Weiyi et al. (2023-01-12). "Structures of the entire human opioid receptor family" (in en). Cell 186 (2): 413–427.e17. doi:10.1016/j.cell.2022.12.026. PMID 36638794.
- ↑ "Dynorphin A 1-8". Dynorphin A 1-8. Human Metabolome Database. 27 September 2017. http://www.hmdb.ca/metabolites/HMDB0012933. Retrieved 20 October 2017.
- ↑ 4.0 4.1 4.2 "Dynorphin A-(1-8): Biological activity". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=1621. "Principal endogenous agonists at κ receptor"
- ↑ Chen, Yuxiang; Chen, Bo; Wu, Tingting; Zhou, Fangfang; Xu, Fei (2022-08-05). "Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A" (in en). Protein & Cell 14 (6): 464–468. doi:10.1093/procel/pwac033. ISSN 1674-800X. PMID 37285260. PMC 10246719. https://academic.oup.com/proteincell/advance-article/doi/10.1093/procel/pwac033/6656488.
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