Chemistry:L-759,656
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Short description: Chemical compound
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| Formula | C26H40O2 |
| Molar mass | 384.604 g·mol−1 |
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L-759,656 is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1,[1] although it is still not as selective as newer agents such as HU-308.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.[2][3]
See also
- Delta-11-Tetrahydrocannabinol
- L-759,633
- L-768,242
References
- ↑ "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630". British Journal of Pharmacology 126 (3): 665–72. February 1999. doi:10.1038/sj.bjp.0702351. PMID 10188977.
- ↑ "The search for selective ligands for the CB2 receptor". Current Pharmaceutical Design 6 (13): 1323–37. September 2000. doi:10.2174/1381612003399347. PMID 10903395.
- ↑ "CB2 receptor ligands". Mini Reviews in Medicinal Chemistry 5 (7): 641–9. July 2005. doi:10.2174/1389557054368844. PMID 16026310.
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