Chemistry:Imagabalin
From HandWiki
Short description: Chemical compound
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| Other names | PD-0332334; PD-332,334 |
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| Formula | C9H19NO2 |
| Molar mass | 173.256 g·mol−1 |
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Imagabalin (INN, USAN; PD-0332334) was an investigational drug that acts as a ligand for the α2δ subunit of the voltage-dependent calcium channel,[1] with some selectivity for the α2δ1 subunit over α2δ2.[2] It was under development by Pfizer as a pharmaceutical medication due to its hypothesized anxiolytic, analgesic, hypnotic, and anticonvulsant-like activity. It reached phase-III clinical trials for treatment of generalized anxiety disorder; however, the trials were terminated by the manufacturer.[3][4][5][6] The drug is no longer under development.
See also
- Atagabalin
- PD-217,014
- Gabapentinoids
References
- ↑ "Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology". Brain Research 1401: 1–9. July 2011. doi:10.1016/j.brainres.2011.05.025. PMID 21664606.
- ↑ Larry Ereshefsky (2008). "Therapies in the Pipeline for Sleep Disorders: Focus on Novel Mechanisms and Disease Models" (PDF) (Press release). p. 11. Retrieved 2012-04-22.
- ↑ Pfizer (2012-11-09). A Phase 3, Randomized, Double-Blind, Parallel Group, 10-Week Placebo Controlled Fixed Dose Study Of PD 0332334 And Paroxetine Evaluating The Efficacy And Safety Of PD 0332334 For The Treatment Of Generalized Anxiety Disorder. https://clinicaltrials.gov/ct2/show/NCT00658008.
- ↑ Pfizer (2012-11-09). A Phase 3, Randomized, Double-Blind, Parallel Group, 10-Week Placebo Controlled Fixed Dose Study Of PD 0332334 And Paroxetine Evaluating The Efficacy And Safety Of PD 0332334 For The Treatment Of Generalized Anxiety Disorder. https://clinicaltrials.gov/ct2/show/NCT00658372.
- ↑ Pfizer (2012-11-09). A Phase 3, Randomized, Double-Blind, Parallel Group, 10-Week Placebo Controlled Fixed Dose Study of PD 0332334 and Paroxetine Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder. https://clinicaltrials.gov/ct2/show/NCT00658762.
- ↑ Pfizer (2012-11-09). A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder. https://clinicaltrials.gov/ct2/show/NCT00735267.
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