Chemistry:Hemorphin-4
From HandWiki
Short description: Endogenous opioid peptide
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| IUPAC name
(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid
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| Other names
L-tyrosyl-L-prolyl-L-tryptophyl-L-threonine
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C29H35N5O7 | |
| Molar mass | 565.618 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Hemorphin-4 is an endogenous opioid peptide of the hemorphin family which possesses antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.[1][2] It is a tetrapeptide with the amino acid sequence Tyr-Pro-Trp-Thr. Hemorphin-4 has affinities for the μ-, δ-, and κ-opioid receptors that are in the same range as the structurally related β-casomorphins, although affinity to the κ-opioid receptor is markedly higher in comparison.[3] It acts as an agonist at these sites.[4] Hemorphin-4 also has inhibitory effects on angiotensin-converting enzyme (ACE),[5] and as a result, may play a role in the regulation of blood pressure.[3] Notably, inhibition of ACE also reduces enkephalin catabolism.[6]
See also
References
- ↑ "Novel opioid peptides derived from hemoglobin: hemorphins". European Journal of Pharmacology 125 (2): 309–10. June 1986. doi:10.1016/0014-2999(86)90044-0. PMID 3743640.
- ↑ "Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo". Peptides 10 (4): 747–51. 1989. doi:10.1016/0196-9781(89)90107-1. PMID 2587417.
- ↑ 3.0 3.1 "Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin". European Journal of Pharmacology 166 (3): 523–6. August 1989. doi:10.1016/0014-2999(89)90368-3. PMID 2553436.
- ↑ "Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1)". Peptides 13 (4): 623–31. 1992. doi:10.1016/0196-9781(92)90165-Y. PMID 1359507.
- ↑ "Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity". FEBS Letters 287 (1–2): 39–41. August 1991. doi:10.1016/0014-5793(91)80011-Q. PMID 1652464.
- ↑ "Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes". Neurochemistry International 4 (5): 389–96. 1982. doi:10.1016/0197-0186(82)90081-X. PMID 20487892.
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