Biology:Integrin alpha 2b
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Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.[1] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[2]
Interactions
ITGA2B has been shown to interact with AUP1[3] and CLNS1A.[4]
See also
- Cluster of differentiation
- Glycoprotein IIb/IIIa
References
- ↑ "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports 9 (1): 18577. December 2019. doi:10.1038/s41598-019-54976-4. PMID 31819097. Bibcode: 2019NatSR...918577S.
- ↑ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674.
- ↑ Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. (United States) 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.
- ↑ Larkin, Deirdre; Murphy Derek; Reilly Dermot F; Cahill Martha; Sattler Ellen; Harriott Pat; Cahill Dolores J; Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. (United States) 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.
Further reading
- Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
- "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4 (5): 317–22. 1997. doi:10.1097/00062752-199704050-00004. PMID 9288464.
- "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. 1999. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
- Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization.". Am. J. Cardiol. 82 (8B): 36P–42P. doi:10.1016/S0002-9149(98)00662-6. PMID 9809890.
- Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936 (1): 340–54. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. Bibcode: 2001NYASA.936..340B.
- "AlphaIIbbeta3 and its antagonism at the new millennium.". Thromb. Haemost. 86 (1): 34–40. 2002. doi:10.1055/s-0037-1616198. PMID 11487023.
- "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. 2004. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
- Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.
- "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. 2005. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
- Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMID 16322781.
- "Platelet integrin alpha(IIb)beta(3): activation mechanisms.". J. Thromb. Haemost. 5 (7): 1345–52. 2007. doi:10.1111/j.1538-7836.2007.02537.x. PMID 17635696.
External links
- CD41+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P08514 (Human Integrin alpha-IIb) at the PDBe-KB.
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