Biology:IL13RA2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[1]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[1]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. [2][3][4][5]

See also

  • Interleukin-13 receptor

References

  1. ↑ 1.0 1.1 "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598. 
  2. ↑ "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research 69 (22): 8678–85. November 2009. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609. http://cancerres.aacrjournals.org/content/69/22/8678. 
  3. ↑ "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer 107 (6): 1407–18. September 2006. doi:10.1002/cncr.22134. PMID 16902988. 
  4. ↑ "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports 9 (1): 1281. February 2019. doi:10.1038/s41598-019-39018-3. PMID 30718742. Bibcode: 2019NatSR...9.1281O. 
  5. ↑ "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research 60 (5): 1168–72. March 2000. PMID 10728667. http://cancerres.aacrjournals.org/content/60/5/1168. 

Further reading

  • "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". The Journal of Allergy and Clinical Immunology 118 (4): 858–65. October 2006. doi:10.1016/j.jaci.2006.06.041. PMID 17030238. 
  • "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". The Journal of Biological Chemistry 271 (28): 16921–6. July 1996. doi:10.1074/jbc.271.28.16921. PMID 8663118. 
  • "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". The Journal of Biological Chemistry 272 (14): 9474–80. April 1997. doi:10.1074/jbc.272.14.9474. PMID 9083087. 
  • "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". European Journal of Immunology 27 (4): 971–8. April 1997. doi:10.1002/eji.1830270425. PMID 9130652. 
  • "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics 42 (1): 141–5. May 1997. doi:10.1006/geno.1997.4628. PMID 9177784. 
  • "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". Journal of Immunology 161 (5): 2317–24. September 1998. doi:10.4049/jimmunol.161.5.2317. PMID 9725226. 
  • "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics 51 (11): 974–81. September 2000. doi:10.1007/s002510000225. PMID 11003391. 
  • "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". The Journal of Biological Chemistry 276 (27): 25114–20. July 2001. doi:10.1074/jbc.M100936200. PMID 11352909. 
  • "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". The Journal of Biological Chemistry 277 (12): 10387–93. March 2002. doi:10.1074/jbc.M108109200. PMID 11786536. 
  • "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clinical Cancer Research 8 (9): 2851–5. September 2002. PMID 12231526. 
  • "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". The Journal of Investigative Dermatology 119 (5): 1114–20. November 2002. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201. 
  • "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Annals of the New York Academy of Sciences 973 (1): 207–9. November 2002. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861. Bibcode: 2002NYASA.973..207D. 
  • "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-Oncology 5 (3): 179–87. July 2003. doi:10.1215/s1152851702000510. PMID 12816724. 
  • "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". The Journal of Biological Chemistry 280 (26): 24915–22. July 2005. doi:10.1074/jbc.M502571200. PMID 15870068. 
  • "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nature Medicine 12 (1): 99–106. January 2006. doi:10.1038/nm1332. PMID 16327802. 
  • "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". Journal of Immunology 176 (12): 7495–501. June 2006. doi:10.4049/jimmunol.176.12.7495. PMID 16751396. 
  • "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer 107 (6): 1407–18. September 2006. doi:10.1002/cncr.22134. PMID 16902988. 
  • "IL13RA2 gene polymorphisms are associated with systemic sclerosis". The Journal of Rheumatology 33 (10): 2015–9. October 2006. PMID 16981293. 

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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