Chemistry:Norgestomet
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| Clinical data | |
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| Trade names | Syncro-Mate B, Crestar |
| Other names | Norgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate |
| Drug class | Progestogen; Progestin; Progestogen ester |
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| CAS Number | |
| PubChem CID | |
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| Chemical and physical data | |
| Formula | C23H32O4 |
| Molar mass | 372.505 g·mol−1 |
| 3D model (JSmol) | |
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Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2]
Uses
Veterinary
Norgestomet is used in veterinary medicine.
Pharmacology
Pharmacodynamics
Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3]
Chemistry
Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][4]
History
Norgestomet was developed and introduced for veterinary use in the mid-1970s.[5]
Society and culture
Generic names
Norgestomet is the generic name of the drug and its INN, USAN, and BAN.[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.[1][4][6]
Brand names
Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 887–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA887.
- ↑ "The Ability of Norgesomet Impregnated Poly(dimethylsiloxane) to Maintain Pregnancy Subsequent to Ovarietomy". Progress in Biomedical Polymers. Springer Science & Business Media. 1 July 1990. pp. 356–. ISBN 978-0-306-43523-2. https://books.google.com/books?id=-qXTBH9-an0C&pg=PA356.
- ↑ "Basis of norgestomet action as a progestogen in cattle". Domestic Animal Endocrinology 10 (1): 21–30. January 1993. doi:10.1016/0739-7240(93)90005-v. PMID 8467644.
- ↑ 4.0 4.1 4.2 4.3 "Norgestomet". Drugs.com. https://www.drugs.com/international/norgestomet.html.
- ↑ "Artificial Control O Oestrus and Ovulation". Controlled Breeding in Farm Animals. Elsevier. 22 October 2013. pp. 40–. ISBN 978-1-4832-8569-6. https://books.google.com/books?id=mEgvBQAAQBAJ&pg=PA40.
- ↑ "Effect of time of insemination and calf removal after estrus synchronization in beef cattle". 1979. http://krex.k-state.edu/dspace/handle/2097/27088.
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