Biology:Melanotransferrin

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

Further reading

• "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.". Oncogene 26 (42): 6113–24. 2007. doi:10.1038/sj.onc.1210442. PMID 17452986. 
• "Human melanotransferrin (p97) has only one functional iron-binding site.". FEBS Lett. 298 (2–3): 215–8. 1992. doi:10.1016/0014-5793(92)80060-T. PMID 1544447. 
• "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.". FEBS Lett. 305 (1): 55–61. 1992. doi:10.1016/0014-5793(92)80654-Y. PMID 1633859. 
• "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. 1986. doi:10.1073/pnas.83.5.1261. PMID 2419904. PMC 323055. Bibcode: 1986PNAS...83.1261R. http://authors.library.caltech.edu/5996/1/ROSpnas86.pdf. 
• "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.". J. Exp. Med. 169 (2): 585–90. 1989. doi:10.1084/jem.169.2.585. PMID 2463331. 
• "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study.". Liver 9 (2): 110–9. 1989. doi:10.1111/j.1600-0676.1989.tb00387.x. PMID 2540389. 
• "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor.". Am. J. Hum. Genet. 38 (4): 540–8. 1986. PMID 3010712. 
• "Chromosomal sublocalization of the human p97 melanoma antigen.". Hum. Genet. 72 (4): 294–6. 1986. doi:10.1007/BF00290951. PMID 3754536. 
• "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.". Nature 303 (5912): 70–2. 1983. doi:10.1038/303070a0. PMID 6843660. Bibcode: 1983Natur.303...70P. 
• "A novel iron uptake mechanism mediated by GPI-anchored human p97.". EMBO J. 14 (17): 4178–86. 1995. doi:10.1002/j.1460-2075.1995.tb00091.x. PMID 7556058. 
• "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.". J. Biol. Chem. 269 (4): 3034–40. 1994. doi:10.1016/S0021-9258(17)42043-6. PMID 8300636. 
• "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium.". Brain Res. 712 (1): 117–21. 1996. doi:10.1016/0006-8993(96)88505-2. PMID 8705293. 
• "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.". Am. J. Pathol. 150 (6): 2143–52. 1997. PMID 9176405. 
• Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID 10691965. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D. 
• "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. 2001. doi:10.1101/gr.gr-1640r. PMID 11337467. 
• "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1–3): 350–2. 2002. doi:10.1016/S0014-5793(02)02248-2. PMID 11852110. 
• "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.". Eur. J. Biochem. 269 (18): 4435–45. 2002. doi:10.1046/j.1432-1033.2002.03140.x. PMID 12230555. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.". Exp. Mol. Pathol. 74 (2): 140–7. 2003. doi:10.1016/S0014-4800(03)00012-1. PMID 12710945. 

External links

• MFI2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.