Chemistry:2-Cl-HHC
2-Cl-HHC (2-chloro-hexahydrocannabinol) is a chlorinated derivative of hexahydrocannabinol which has been sold as a designer drug, and is presumed to have cannabinoid activity. It was first identified as a component of a cannabinoid e-cigarette liquid in Japan in 2025 which was represented as being free from illicit cannabinoids such as THC. The active ingredient instead was identified as a mixture of 2-Cl-HHC and 4-Cl-HHC along with 2,4-dichloro-HHC and trace amounts of other chlorinated phytocannabinoid derivatives, as well as the ester Δ9-THCB-O-butanoate.[1] While chlorinated derivatives of THC such as 9-Cl-HHC had previously been identified, their biological activity has not been studied.[2] 2-Cl-HHC has since been added to the controlled drugs list in Hungary.[3][4]
See also
- 1'-Dimethyl-Δ9-THCH
- 2-Allyl-Δ8-THC-O-acetate
- 4'-Fluorocannabidiol
- Adamantyl-HHC
- THC butanenitrile oxime
References
- ↑ "Identification of Novel THC Analogs: Chloro Derivatives of Hexahydrocannabinol and Tetrahydrocannabibutol Butanoate in an Oil Product Obtained in Japan". Drug Testing and Analysis 17 (11): 2170–2177. November 2025. doi:10.1002/dta.3927. PMID 40880172.
- ↑ "Addition and elimination of HCl to tetrahydrocannabinol isomers. A method for the preparation of stereospecifically 2H‐labeled cannabinoids.". Journal of Labelled Compounds and Radiopharmaceuticals 41 (2): 121–130. February 1998.
- ↑ "18 ÚJ SZER Kerül Tiltólistára: de ELÉG-E a Tiltás?". 2026-07-08. https://drogriporter.hu/18-uj-szer-kerul-tiltolistara-de-vajon-mi-lesz-ennek-a-hatasa/.
- ↑ "Társadalmi egyeztetés az új pszichoaktív anyagok szabályozásáról.". https://kormany.hu/dokumentumtar/tarsadalmi-egyeztetes-az-uj-pszichoaktiv-anyagok-szabalyozasarol.
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