Chemistry:LY2828360

From HandWiki

LY2828360 is a drug which acts as a potent, selective and long acting agonist of the cannabinoid CB2 receptor. It was effective against neuropathic pain and allodynia in animal models, but was unsuccessful in human clinical trials against arthritis pain.[1][2][3][4]

References

  1. ↑ "Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence". Molecular Pharmacology 93 (2): 49–62. February 2018. doi:10.1124/mol.117.109355. PMID 29192123. 
  2. ↑ "The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence". European Journal of Pharmacology 886. November 2020. doi:10.1016/j.ejphar.2020.173544. PMID 32896549. 
  3. ↑ "Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression". Cannabis and Cannabinoid Research 6 (5): 389–400. October 2021. doi:10.1089/can.2020.0059. PMID 33998863. 
  4. ↑ "The cannabinoid CB2 agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats". Neuropharmacology 265. March 2025. doi:10.1016/j.neuropharm.2024.110257. PMID 39644993. 



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