Chemistry:Lafadofensine

From HandWiki

Lafadofensine (INN), also known as (3S)-N,N-bis(4-fluorophenyl)pyrrolidin-3-amine, is a drug described as an antidepressant which has not been marketed at this time.[1][2][3] It is said to act as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).[1] The drug was first described by 2010[4] and its INN was proposed by 2021.[5]

See also

References

  1. 1.0 1.1 World Health Organization (2024). "Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances, 2024". World Health Organization. p. 102. https://iris.who.int/bitstream/handle/10665/379226/9789240099388-eng.pdf#page=108. "-fensine norepinephrine, serotonin, dopamine reuptake inhibitors brasofensine (76), diclofensine (44), lafadofensine (126), liafensine (109), nomifensine (24), perafensine (44), tesofensine (89)" 
  2. "LAFADOFENSINE". https://drugs.ncats.io/substance/7HFV4D3KJL. 
  3. "Lafadofensine". https://pubchem.ncbi.nlm.nih.gov/compound/15605612. 
  4. Akazawa K, Amada N, Ito N, Kurimura M, Masumoto T, Matsuzaki T, Menjo Y, Miyamura S, Morita C, Nakajima S, Ohashi S, Sakata Y, Sakurai Y, Sasaki H, Shinohara T, Sugino H, Tai K, Taira S, Takemura N, Tomoyasu T, Watanabe A, Yamashita J, "N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors", AU patent 2006/244851B2, issued 10 June 2010
  5. "Proposed INN: List 126 International Nonproprietary Names for Pharmaceutical Substances (INN)". WHO Drug Information 35 (4). 2021. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf.