Chemistry:Naphthoylindoles
From HandWiki
Naphthoylindoles are a class of synthetic cannabinoids.[1]
Pharmacology
Behaving similarly in vivo to endocannabinoids such as anandamide or 2-arachidonoylglycerol (2-AG), naphthoylindoles can bind to endocannabinoid receptors in animals, presenting as CB1 and/or CB2 partial/full agonists.
History
They have gained notoriety over the years for illicit usage and distribution in Europe and North America, typically marketed as "herbal incense blends."[2]
See also
- Structural scheduling of synthetic cannabinoids
- List of JWH cannabinoids, includes many naphthoylindoles
- Naphthoyl, an acyl group, derived, in this case, from 1-naphthoic acid
- Indole
References
- ↑ Manera, C; Tuccinardi, T; Martinelli, A (April 2008). "Indoles and related compounds as cannabinoid ligands". Mini Reviews in Medicinal Chemistry 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.
- ↑ "Synthetic cannabinoids drug profile". EMCDDA. https://www.emcdda.europa.eu/publications/drug-profiles/synthetic-cannabinoids_en.
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