Chemistry:RU-1205
From HandWiki
RU-1205 is a kappa opioid receptor agonist used for pain treatment. It has high bioavailability (44.17 and 56.03% upon peroral and subcutaneous introduction).[1]
Granulated RU-1205 produced maximum analgesic effect within 4-h investigation and retained higher analgesic activity compared to that of parent substance.[2]
RU-1205 does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.[3]
See also
- List of Russian drugs
References
- ↑ "[The absolute bioavailability of benzimidazole derivative RU-1205 in rats]". Eksperimental'naia i Klinicheskaia Farmakologiia 77 (1): 17–19. 2014. PMID 24649597.
- ↑ "[Pharmacokinetic and analgesic properties of tabletized dosage form of RU-1205-new imidazobenzimidazole derivative with kappa agonist activity]". Eksperimental'naia i Klinicheskaia Farmakologiia 77 (7): 27–30. 2014. PMID 25322651.
- ↑ "Studying the Physical Dependence on and Tolerance to the Antinociceptive Effect of Ru-1205 Substance". Eksperimental'naia i Klinicheskaia Farmakologiia 79 (4): 8–11. August 2016. PMID 29949697.
Pain and nociception]] | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| By region/system |
| ||||||||||
| Tests | |||||||||||
| Related concepts | |||||||||||
 | 0.00  (0 votes) |
