Chemistry:FUB-APINACA
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| Formula | C25H26FN3O |
| Molar mass | 403.501 g·mol−1 |
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FUB-APINACA (also known as A-FUBINACA according to the EMCCDA framework for naming synthetic cannabinoids[1] and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[2] It is an analog of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.
Pharmacology
FUB-APINACA acts as a full agonist with a binding affinity of 1.06 nM at CB1 and 0.174 nM at CB2 cannabinoid receptors.[3]
Legal status
In the United States, FUB-APINACA was temporarily emergency scheduled by the DEA in 2019.[4] and made a permanent Schedule I Controlled Substance nationwide on April 7, 2022.[5] Previously, it was illegal only in Alabama (listed as FUB-AKB48).[6]
Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.[7]
See also
- 5F-ADB
- 5F-AMB
- AB-FUBINACA
- AB-CHFUPYCA
- AB-PINACA
- ADAMANTYL-THPINACA
- ADB-CHMINACA
- ADB-FUBINACA
- ADB-PINACA
- ADBICA
- APP-FUBINACA
- FAB-144
- MDMB-CHMINACA
- MDMB-FUBINACA
- PX-3
References
- ↑ Pulver B, Fischmann S, Gallegos A, Christie R. EMCDDA framework and practical guidance for naming synthetic cannabinoids. Drug Test Anal. 2023;15(3): 255‐276. doi:10.1002/dta.3403
- ↑ "FUB-AKB48". Cayman Chemical. https://www.caymanchem.com/app/template/Product.vm/catalog/15937.
- ↑ "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology 34 (2): 329–343. 2016. doi:10.1007/s11419-016-0320-2. PMID 27429655.
- ↑ "Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I". Federal Register. 2019-04-16. https://www.federalregister.gov/documents/2019/04/16/2019-07460/schedules-of-controlled-substances-temporary-placement-of-5f-edmb-pinaca-5f-mdmb-pica-fub-akb48.
- ↑ "Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I". Federal Register 87 (67). 7 April 2022. https://www.govinfo.gov/content/pkg/FR-2022-04-07/pdf/2022-07320.pdf.
- ↑ Alabama Senate Bill SB 333: Controlled Substances
- ↑ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Folkhälsomyndigheten. http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/.
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