Chemistry:Etrinabdione
From HandWiki
Short description: Chemical compound
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| Formula | C28H35NO3 |
| Molar mass | 433.592 g·mol−1 |
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Etrinabdione (VCE-004.8, EHP-101) is a drug structurally related to cannabidiol and HU-331 which has potent antiinflammatory and neuroprotective effects. It acts as a dual agonist of CB2 and PPARγ and is in clinical trials for the treatment of scleroderma.[1][2][3][4][5][6][7][8][9]
See also
References
- ↑ "Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy". Journal of Neuroinflammation 15 (1): 64. March 2018. doi:10.1186/s12974-018-1103-y. PMID 29495967.
- ↑ "EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis". Biochemical Pharmacology 157: 304–313. November 2018. doi:10.1016/j.bcp.2018.07.047. PMID 30076848.
- ↑ "VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity". Scientific Reports 8 (1): 16092. October 2018. doi:10.1038/s41598-018-34259-0. PMID 30382123. Bibcode: 2018NatSR...816092P.
- ↑ "Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis". Biochemical Pharmacology 163: 321–334. May 2019. doi:10.1016/j.bcp.2019.02.029. PMID 30825431.
- ↑ "Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis". Neurobiology of Disease 143: 104994. September 2020. doi:10.1016/j.nbd.2020.104994. PMID 32599064.
- ↑ "Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson's Disease". Molecules 26 (11): 3245. May 2021. doi:10.3390/molecules26113245. PMID 34071302.
- ↑ "Cannabinoquinones: Synthesis and Biological Profile". Biomolecules 11 (7): 991. July 2021. doi:10.3390/biom11070991. PMID 34356614.
- ↑ "A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury". Journal of Neuroinflammation 19 (1): 177. July 2022. doi:10.1186/s12974-022-02540-9. PMID 35810304.
- ↑ "Neuroprotection by the cannabidiol aminoquinone VCE-004.8 in experimental ischemic stroke in mice". Neurochemistry International 165: 105508. May 2023. doi:10.1016/j.neuint.2023.105508. PMID 36863495.
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