Chemistry:SER-601
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C28H38N2O2 |
| Molar mass | 434.624 g·mol−1 |
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SER-601 (COR-167) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist, based on a quinolone-3-carboxylic acid core structure, with 190 times selectivity for CB2 over the related CB1 receptor. It has analgesic effects in animal studies, as well as neuroprotective effects,[1] but without a "cannabis high" due to its low affinity for CB1.[2] A number of related compounds are known, almost all of which have high selectivity for CB2.[3]
See also
References
- ↑ "A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury". Pharmacological Research 66 (6): 555–563. December 2012. doi:10.1016/j.phrs.2012.08.003. PMID 23036353.
- ↑ "Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo". Journal of Medicinal Chemistry 51 (16): 5075–5084. August 2008. doi:10.1021/jm800552f. PMID 18680276.
- ↑ "Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands". Journal of Medicinal Chemistry 53 (16): 5915–5928. August 2010. doi:10.1021/jm100123x. PMID 20718492.
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