Chemistry:8,11-Dihydroxytetrahydrocannabinol
From HandWiki
Short description: Chemical compound
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| Formula | C21H30O4 |
| Molar mass | 346.467 g·mol−1 |
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8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ9-THC) is an active metabolite of THC, the main active component of cannabis. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than 11-Hydroxy-THC, making 8,11-dihydroxy-THC potentially useful for drug testing to distinguish between recent cannabis use and use longer in the past.[1][2][3]
See also
- 3'-Hydroxy-THC
- 7-Hydroxycannabidiol
- 11-Hydroxy-Delta-8-THC
- 11-Nor-9-carboxy-THC
- Cannabitriol
- Cannabiripsol
References
- ↑ "Synthesis of metabolites of delta-9-tetrahydrocannabinol". Journal of the American Chemical Society 97 (13): 3798–3802. June 1975. doi:10.1021/ja00846a040. PMID 1141589.
- ↑ "Discriminative stimulus functions of cannabinoids/cannabimimetics". Drug Discrimination: Applications to Drug Abuse Research. NIDA Research Monograph. 1991. pp. 75–99.
- ↑ "8β-OH-THC and 8β,11-diOH-THC-minor metabolites with major informative value?". International Journal of Legal Medicine 132 (1): 157–164. January 2018. doi:10.1007/s00414-017-1692-5. PMID 28983686.
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