Chemistry:BMS-F
From HandWiki
Short description: Chemical compound
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| Formula | C27H33N3O5 |
| Molar mass | 479.577 g·mol−1 |
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BMS-F is a chemical from the aminoalkylindole family invented by Bristol-Myers Squibb around 1999,[1] that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 8 nM at CB2 and 500x selectivity over the related CB1 receptor. It has antiinflammatory effects and inhibits release of TNF-α.[2][3]
See also
References
- ↑ Leftheris K, Zhao R, Chen BC, Kiener P, Wu H, Pandit CR, Wrobleski S, Chen P, Hynes J, Longphre M, Norris DJ, Spergel S, Tokarski J, "Cannabinoid Receptor Modulators, Their Processes of Preparation, and use of Cannabinoid Receptor Modulators for Treating Respiratory and Non-Respiratory Diseases", WO patent application 0158869, published 16 August 2001, assigned to Bristol-Myers Squibb
- ↑ "C-3 Amido-indole cannabinoid receptor modulators". Bioorganic & Medicinal Chemistry Letters 12 (17): 2399–2402. September 2002. doi:10.1016/s0960-894x(02)00466-3. PMID 12161142.
- ↑ "The Spicy Story of Cannabimimetic Indoles". Molecules 26 (20): 6190. October 2021. doi:10.3390/molecules26206190. PMID 34684770.
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