Chemistry:Cannabinor
From HandWiki
Short description: Chemical compound
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| Formula | C28H36O6 |
| Molar mass | 468.590 g·mol−1 |
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Cannabinor (PRS-211,375) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist.[1][2] It is classed as a "nonclassical" cannabinoid with a chemical structure similar to that of cannabidiol. It has a CB2 affinity of 17.4 nM vs 5,585 nM at CB1, giving it over 300× selectivity for CB2.[3] It showed analgesic effects in animal studies especially in models of neuropathic pain, but failed in Phase IIb human clinical trials due to lack of efficacy.[4]
See also
References
- ↑ "Effects of cannabinor, a novel selective cannabinoid 2 receptor agonist, on bladder function in normal rats". European Urology 57 (6): 1093–100. June 2010. doi:10.1016/j.eururo.2010.02.027. PMID 20207474.
- ↑ "Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction". The Journal of Urology 185 (2): 731–6. February 2011. doi:10.1016/j.juro.2010.09.080. PMID 21168864.
- ↑ "The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation". Perspectives in Medicinal Chemistry 8: 17–39. 2016. doi:10.4137/PMC.S32171. PMID 27398024.
- ↑ "Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands". Current Medicinal Chemistry 21 (2): 187–203. 2013. doi:10.2174/09298673113206660296. PMID 24164198.
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