Chemistry:Cod-THC

From HandWiki

Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1][2][3]

THC can partially inhibit CYP2D6, which is the enzyme that transforms codeine into its active metabolite morphine.[4][5] It's not well understood how THC may impact codeines metabolism in humans.

See also

References

  1. ↑ ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry 21 (18): 3715–3732. May 2023. doi:10.1039/d3ob00068k. PMID 36825573. 
  2. ↑ Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management", US patent 2008176885A1, published 24 July 2008, assigned to University of Kentuckyand Insys Therapeutics Inc
  3. ↑ "Improving the Use of Drug Combinations Through the Codrug Approach". Prodrugs and Targeted Delivery. Methods and Principles in Medicinal Chemistry. 47. 2010. pp. 345–383. doi:10.1002/9783527633166.ch13. ISBN 978-3-527-32603-7. 
  4. ↑ "Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions". Drug Metabolism and Disposition 49 (12): 1070–1080. December 2021. doi:10.1124/dmd.121.000442. PMID 34493602. 
  5. ↑ "Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms". Biochemistry 60 (37): 2749–2760. September 2021. doi:10.1021/acs.biochem.1c00158. PMID 34491040. 



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