Chemistry:THC-VHS

From HandWiki

THC valine hemisuccinate (THC-VHS, NB-1111, SBI-100) is a synthetic prodrug of tetrahydrocannabinol, developed at the University of Mississippi as a stabilised formulation for ophthalmic administration, for use in the treatment of glaucoma and other eye conditions requiring reduction in intraocular pressure.[1][2][3][4][5]

See also

References

  1. ↑ "Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits". Translational Vision Science & Technology 8 (5): 15. September 2019. doi:10.1167/tvst.8.5.15. PMID 31588378. 
  2. ↑ "Effect of surfactant concentration and sterilization process on intraocular pressure-lowering activity of Δ9-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions". Drug Delivery and Translational Research 11 (5): 2096–2107. October 2021. doi:10.1007/s13346-020-00871-9. PMID 33169348. 
  3. ↑ "Impact of mucoadhesive agent inclusion on the intraocular pressure lowering profile of Δ9-tetrahydrocannabinol-valine-hemisuccinate loaded nanoemulsions in New Zealand white rabbits". International Journal of Pharmaceutics 616. March 2022. doi:10.1016/j.ijpharm.2022.121564. PMID 35151817. 
  4. ↑ Elsohly MA, Gul W, Repka MA, Majumdar S, "Compositions containing delta-9-THC-amino acid esters and process of preparation.", US patent 8809261, issued 19 August 2014
  5. ↑ Hsu E, Kumar U, Kumar R, "Compositions and methods for use of cannabinoids for neuroprotection", WO patent 2020/215164, published 29 October 2020



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