Chemistry:PRX-14040
From HandWiki
PRX-14040 is a selective dopamine reuptake inhibitor that was developed by Prexa Pharmaceuticals.[1][2][3] It has 28-fold selectivity for the dopamine transporter over the norepinephrine transporter.[2] Similarly to various other dopamine reuptake inhibitors, the drug has been found to reverse motivational deficits induced by the dopamine depleting agent tetrabenazine in animals.[1][2]
See also
- CT-005404
- MRZ-9547
References
- ↑ 1.0 1.1 "The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation". Pharmacol Rev 70 (4): 747–762. October 2018. doi:10.1124/pr.117.015107. PMID 30209181.
- ↑ 2.0 2.1 2.2 Desibhatla, Mukund (16 June 2021). "The Development and Evaluation of Novel DA Transport Inhibitors and their Effects on Effort-Related Motivation: A Review". Honors Scholar Theses. https://digitalcommons.lib.uconn.edu/srhonors_theses/787/. Retrieved 10 August 2024.
- ↑ "Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040". Pharmacol Biochem Behav 148: 84–91. September 2016. doi:10.1016/j.pbb.2016.06.004. PMID 27296079.
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