Chemistry:ADB-FUBIATA
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| Formula | C23H26FN3O2 |
| Molar mass | 395.478 g·mol−1 |
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ADB-FUBIATA (AD-18, FUB-ACADB, ADB-FUBIACA) is a synthetic cannabinoid compound first identified in 2021. It is closely related in structure to the older compound ADB-FUBICA but with the amide linker group extended by the addition of a methylene bridge. It started to be sold as an ingedient in grey-market synthetic cannabis blends following the introduction of legislation in China which for the first time introduced general controls on various classes of synthetic cannabinoids,[1] but did not encompass compounds where the linker group had been extended in this fashion. ADB-FUBIATA has many times lower affinity for cannabinoid receptors than ADB-FUBICA with an EC50 of only 635 nM at CB1, but retains full agonist activity at this target, while being practically inactive at CB2.[2][3]
Legality
In the United States ADB-FUBIATA is unscheduled at the federal level as of May 22nd, 2023 but may be considered under the federal analogue act if sold for human consumption. North Dakota has placed ADB-FUBIATA into Schedule I on 04/27/2023. [4]
See also
References
- ↑ "关于将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告" (in Chinese). Ministry of Public Security of the People's Republic of China. 12 May 2021. https://app.mps.gov.cn/gdnps/pc/content.jsp?id=7881703.
- ↑ "A new cannabinoid receptor 1 selective agonist evading the 2021 "China ban": ADB-FUBIATA". Drug Testing and Analysis 14 (9): 1639–1644. September 2022. doi:10.1002/dta.3285. PMID 35570246. https://biblio.ugent.be/publication/01GQ757043ZZ4MNSKMZ52FAKJ1.
- ↑ "Identification of the synthetic cannabinoid-type new psychoactive substance, CH-PIACA, in seized material". Drug Testing and Analysis 14 (9): 1645–1651. September 2022. doi:10.1002/dta.3333. PMID 35687099.
- ↑ "AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency.". Sixty-eighth Legislative Assembly of North Dakota in Regular Session. 3 January 2023. https://www.ndlegis.gov/prod/assembly/68-2023/regular/documents/23-8099-04000.pdf.
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