Biology:Concentrative nucleoside transporter 1

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Short description: Protein found in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.[1][2]

See also

References

  1. ↑ "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol 272 (2 Pt 1): C707–14. Apr 1997. doi:10.1152/ajpcell.1997.272.2.C707. PMID 9124315. 
  2. ↑ "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9154. 

Further reading

  • "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).". Mol. Membr. Biol. 18 (1): 65–72. 2001. doi:10.1080/09687680118530. PMID 11396613. 
  • "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.". Mol. Membr. Biol. 15 (4): 203–11. 1999. doi:10.3109/09687689709044322. PMID 10087507. 
  • "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.". J. Biol. Chem. 274 (35): 24475–84. 1999. doi:10.1074/jbc.274.35.24475. PMID 10455109. 
  • "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.". Mol. Pharmacol. 59 (6): 1542–8. 2001. doi:10.1124/mol.59.6.1542. PMID 11353816. 
  • "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.". J. Biol. Chem. 277 (40): 37711–7. 2002. doi:10.1074/jbc.M204986200. PMID 12097333. 
  • "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction.". J. Pharmacol. Exp. Ther. 303 (2): 487–96. 2002. doi:10.1124/jpet.102.038315. PMID 12388627. 
  • "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia.". Blood 101 (6): 2328–34. 2003. doi:10.1182/blood-2002-07-2236. PMID 12411296. 
  • "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
  • "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity.". Clin. Cancer Res. 9 (13): 5000–8. 2004. PMID 14581375. 
  • "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes.". Mol. Membr. Biol. 21 (1): 1–10. 2004. doi:10.1080/0968768031000140836. PMID 14668133. 
  • "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.". Mol. Pharmacol. 65 (3): 512–9. 2004. doi:10.1124/mol.65.3.512. PMID 14978229. 
  • "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.". Int. J. Cancer 112 (6): 959–66. 2004. doi:10.1002/ijc.20524. PMID 15386342. 
  • "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. 2005. doi:10.1152/ajpcell.00192.2004. PMID 15456697. 
  • "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.". Biochem. Biophys. Res. Commun. 353 (2): 381–8. 2007. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757. 
  • "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling.". Biochemistry 46 (6): 1684–93. 2007. doi:10.1021/bi061692s. PMID 17279631. 
  • "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.". Mol. Membr. Biol. 24 (1): 53–64. 2007. doi:10.1080/09687860600942534. PMID 17453413. 
  • "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.". Antivir. Ther. (Lond.) 12 (6): 853–63. 2007. doi:10.1177/135965350701200601. PMID 17926640. 




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