Biology:CD79B

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

See also

• Cluster of differentiation

Further reading

• Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006. 
• "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. 1992. doi:10.1002/eji.1830220641. PMID 1534761. 
• "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. 1994. doi:10.1002/eji.1830240406. PMID 7512031. 
• "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. 1994. doi:10.1016/0161-5890(94)90061-2. PMID 7514267. 
• "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. 1994. doi:10.1016/S0021-9258(17)32545-0. PMID 7516335. 
• "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. 1995. doi:10.1074/jbc.270.19.11590. PMID 7538118. 
• "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. 1995. doi:10.1084/jem.181.6.2077. PMID 7539038. 
• "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. 1995. doi:10.1016/0165-2478(94)00199-2. PMID 7541024. 
• "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. 1995. doi:10.1074/jbc.270.45.27072. PMID 7592958. 
• "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. 1995. doi:10.1016/0161-5890(95)00023-8. PMID 7643857. 
• "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics 40 (2): 145–9. 1994. doi:10.1007/BF00188178. PMID 7913081. 
• "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. 1994. doi:10.4049/jimmunol.153.6.2369. PMID 8077654. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. 1993. doi:10.4049/jimmunol.150.2.491. PMID 8419481. 
• "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics 16 (1): 187–92. 1993. doi:10.1006/geno.1993.1157. PMID 8486355. 
• "The promoter and 5' flanking sequences controlling human B29 gene expression". Blood 87 (2): 666–73. 1996. doi:10.1182/blood.V87.2.666.bloodjournal872666. PMID 8555489. 
• "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia 10 (5): 769–73. 1996. PMID 8656670. 
• "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. 1996. doi:10.1016/0165-2478(95)00071-X. PMID 8747711. 
• "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. 1997. doi:10.4049/jimmunol.158.7.3062. PMID 9120258. 

External links

• CD79B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD79B genome location and CD79B gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.