Chemistry:JZL195

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JZL195
JZL-195 Structure.svg
Names
Preferred IUPAC name
4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
Properties
C24H23N3O5
Molar mass 433.464 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.[1]

See also

References

  1. "Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo". Proceedings of the National Academy of Sciences of the United States of America 106 (48): 20270–5. December 2009. doi:10.1073/pnas.0909411106. PMID 19918051. Bibcode2009PNAS..10620270L.