Chemistry:THC hemisuccinate
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Short description: Chemical compound
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| Formula | C25H34O5 |
| Molar mass | 414.542 g·mol−1 |
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THC hemisuccinate (Δ9-THC-O-hemisuccinate, Dronabinol hemisuccinate) is a synthetic derivative of tetrahydrocannabinol, developed in the 1990s. It is a water-soluble prodrug ester which is converted into THC inside the body, and was developed to overcome the poor bioavailability of THC when taken by non-inhaled routes of administration.[1][2][3]
See also
- THC-O-acetate
- THC-O-phosphate
- SP-111
References
- ↑ "Rectal bioavailability of delta-9-tetrahydrocannabinol from various esters". Pharmacology, Biochemistry, and Behavior 40 (3): 497–502. November 1991. doi:10.1016/0091-3057(91)90353-4. PMID 1666913.
- ↑ "Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys". Journal of Pharmaceutical Sciences 80 (10): 942–5. October 1991. doi:10.1002/jps.2600801008. PMID 1664466.
- ↑ "Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins". AAPS PharmSciTech 11 (2): 509–17. June 2010. doi:10.1208/s12249-010-9401-4. PMID 20333489.
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