Chemistry:Tenilapine

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Short description: Atypical antipsychotic
Tenilapine
INN: tenilapine
Tenilapine.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H16N4S2
Molar mass340.46 g·mol−1
3D model (JSmol)

Tenilapine is an atypical antipsychotic which has never been marketed in the US.

Pharmacodynamics

Tenilapine has a relatively high affinity for the 5-HT2A receptor, and relatively low (micromolar) affinities for dopamine receptors.

Binding affinities
Receptor Ki (nM)
D4 721±300[1]
5-HT2A 40[1]

The ratio of D2 to D4 bonding is similar to that of clozapine.[1] Like many other atypical antipsychotics, it is a potent 5-HT2C antagonist.[2]

References

  1. ↑ 1.0 1.1 1.2 Cite error: Invalid <ref> tag; no text was provided for refs named roth
  2. ↑ "The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies". 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors. 22. Totowa, NJ: Humana Press. 2011. pp. 215–247. doi:10.1007/978-1-60761-941-3_11. ISBN 978-1-60761-940-6. 



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