Chemistry:1-Naphthylmethcathinone
From HandWiki
1-Naphthylmethcathinone (AMAPN) is a monoamine releasing agent of the cathinone and naphthylaminopropane families.[1][2] It is an analogue of methcathinone in which the phenyl ring has been replaced with a 1-naphthalene ring.[1][2]
The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA).[1][2] Its EC50 values for induction of monoamine release are 21.6 nM for serotonin and 55.2 nM for dopamine, whereas the EC50 for norepinephrine was not reported.[1] However, AMAPN induced 92% release of norepinephrine at a concentration of 10,000 nM, indicating that it is an effective norepinephrine releaser as well.[1]
See also
- 1-Naphthylaminopropane (1-NAP)
- 2-Naphthylmethcathinone (BMAPN)
- 2,3-Methylenedioxyamphetamine (2,3-MDA)
- 2,3-Methylenedioxymethamphetamine (2,3-MDMA)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes". Psychopharmacology (Berl) 236 (3): 915–924. March 2019. doi:10.1007/s00213-018-5063-9. PMID 30341459.
- ↑ 2.0 2.1 2.2 Yadav BJ (16 July 2019). Understanding Structure–Activity Relationship of Synthetic Cathinones (Bath Salts) Utilizing Methylphenidate. VCU Scholars Compass (Thesis). doi:10.25772/MJQW-8C64. Retrieved 24 November 2024.
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