Chemistry:Cyclazodone
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| Routes of administration | Oral |
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| Formula | C12H12N2O2 |
| Molar mass | 216.240 g·mol−1 |
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| Chirality | Racemic mixture |
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Cyclazodone is a centrally acting stimulant drug developed by American Cyanamid Company in the 1960s.[1] The drug is related to other drugs such as pemoline and thozalinone. It displayed a favorable therapeutic index and margin of safety in comparison to Pemoline and other N-lower-alkyl-substituted Pemoline derivatives.[2] The patents concluded that Cyclazodone possessed properties efficacious in reducing fatigue and as a potential anorectic.[3] Structural congeners of Pemoline have been described as "excitants with unique properties distinguishing them from the sympathomimetic amines" whilst displaying less stimulatory activity and toxicity compared to amphetamine.[4]
It is included under the World Anti-Doping Agency prohibited list.[5]
Safety
Cyclazodone has not been evaluated by the United States Food and Drug Administration for use in humans as a nootropic, anorectic, or stimulant and thus safety information on Cyclazodone is lacking. However, in studies relating to the therapeutic uses of Cyclazodone, it was noted that Cyclazodone exhibited less cardiotoxic and hepatotoxic effects than D-Amphetamine in studies on mice.[2]
See also
References
- ↑ Howell Jr CF, Hardy RA, Quinones N, "5-Arylidene-2-Amino-2-Oxazolin-4-Ones", US patent 3321470, issued 23 May 1967, assigned to American Cyanamid
- ↑ 2.0 2.1 De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", US patent 3609159, issued 28 September 1971, assigned to Les Laboratoires Dausse
- ↑ De Marne V, Pierre D, Guidicelli RL, Najer H, "5-Phenyl-2-Cyclopropylamino-4-Oxazolinone", GB patent 1005738, issued 29 September 1965, assigned to Les Laboratoires Dausse
- ↑ "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. July 1965. doi:10.1016/0041-008x(65)90042-6. PMID 4378772.
- ↑ "World Anti-Doping Agency 2008 Prohibited List". World Anti-Doping Agency. 22 September 2007. https://www.wada-ama.org/sites/default/files/resources/files/WADA_Prohibited_List_2008_EN.pdf.
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