Chemistry:Phenylbiguanide

Phenylbiguanide
Legal status
Legal status	UN: Unscheduled ;
Identifiers
	IUPAC name 1-Phenylbiguanide;
CAS Number	102-02-3;
PubChem CID	4780;
ChemSpider	4616;
UNII	W8PKA3T2I3;
ChEBI	CHEBI:75377;
ChEMBL	ChEMBL13791;
Chemical and physical data
Formula	C8H11N5
Molar mass	177.211 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	135–142 °C (275–288 °F)
	SMILES c1ccc(cc1)NC(=N)NC(=N)N;
	InChI InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13); Key:CUQCMXFWIMOWRP-UHFFFAOYSA-N;

Short description: Chemical compound

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.^[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.^[2]

Derivatives

↑ "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats". The Journal of Pharmacology and Experimental Therapeutics (Journal of Pharmacology and Experimental Therapeutics) 264 (3): 1440–9. March 1993. PMID 8450478.
↑ "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens". Brain Research (Brain Research.) 543 (2): 354–7. March 1991. doi:10.1016/0006-8993(91)90050-6. PMID 1711914.

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Legal status

Legal status	UN: Unscheduled
Identifiers
IUPAC name 1-Phenylbiguanide
CAS Number	102-02-3
PubChem CID	4780
ChemSpider	4616
UNII	W8PKA3T2I3
ChEBI	CHEBI:75377
ChEMBL	ChEMBL13791
Chemical and physical data
Formula	C₈H₁₁N₅
Molar mass	177.211 g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	135–142 °C (275–288 °F)
SMILES c1ccc(cc1)NC(=N)NC(=N)N
InChI InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13) Key:CUQCMXFWIMOWRP-UHFFFAOYSA-N