Chemistry:4-Hydroxy-3-methoxymethcathinone
From HandWiki
4-Hydroxy-3-methoxymethcathinone (HMMC), or 3-methoxy-4-hydroxy-N-methylcathinone, is a monoamine releasing agent of the amphetamine and cathinone families.[1][2][3] It is an active metabolite of methylone (3,4-methylenedioxymethcathinone; MDMC).[1][2][3] The drug is a very low-potency serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC50 values of 7,210 nM for serotonin, 6,340 nM for norepinephrine, and 5,840 nM for dopamine in rat brain synaptosomes.[1][2] HMMC was first described in the scientific literature by 2011.[3][1][2]
See also
- 3,4-Dihydroxymethcathinone (HHMC; 3,4-DHMC)
- 4-Hydroxy-3-methoxyamphetamine (HMA)
- 4-Hydroxy-3-methoxymethamphetamine (HMMA)
- α-Methyldopamine (3,4-dihydroxyamphetamine; HHA; 3,4-DHA)
- α-Methylepinine (3,4-dihydroxymethamphetamine; HHMA, 3,4-DHMA)
References
- ↑ 1.0 1.1 1.2 1.3 "Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats". Neuropsychopharmacology 42 (3): 649–660. February 2017. doi:10.1038/npp.2016.213. PMID 27658484.
- ↑ 2.0 2.1 2.2 2.3 "Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems". Journal of Psychopharmacology 33 (7): 831–841. July 2019. doi:10.1177/0269881119844185. PMID 31038382.
- ↑ 3.0 3.1 3.2 "Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis". Forensic Toxicology 29 (2): 73–84. 2011. doi:10.1007/s11419-011-0111-8. ISSN 1860-8965. https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=59079fcbf259f3badfaf26a4af53ac227b3c2651.
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