Chemistry:3,4-Isopropylidenedioxyamphetamine
From HandWiki
3,4-Isopropylidenedioxyamphetamine (IDA) is a monoamine releasing agent (MRA) of the amphetamine family related to 3,4-methylenedioxyamphetamine (MDA).[1][2][3] It is considerably less potent than MDA as an MRA in vitro.[3][1] IDA fully substituted for MDMA and LSD in animal drug discrimination tests, albeit with 5- to 7-fold lower potency than MDA.[3][1]
See also
- 3,4-Ethylidenedioxyamphetamine (EIDA)
- 3,4-Ethylenedioxyamphetamine (EDA)
- 3,4-Ethylenedioxymethamphetamine (EDMA)
- 3,4-Ethylenedioxymethcathinone (EDMC)
References
- ↑ 1.0 1.1 1.2 "Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues". Pharmacol Biochem Behav 34 (3): 571–576. November 1989. doi:10.1016/0091-3057(89)90560-1. PMID 2623014.
- ↑ "Evaluating the abuse potential of psychedelic drugs as part of the safety pharmacology assessment for medical use in humans". Neuropharmacology 142: 89–115. November 2018. doi:10.1016/j.neuropharm.2018.01.049. PMID 29427652.
- ↑ 3.0 3.1 3.2 "MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology". Curr Neuropharmacol 11 (5): 521–534. September 2013. doi:10.2174/1570159X11311050007. PMID 24403876. "Additionally, EDA (ethyl[idene]dioxyamphetamine) has been demonstrated to be nearly equipotent to MDA in its ability to induce [3H]5-HT and [3H]dopamine release from rat hippocampal slices, whereas IDA (isopropylidenedioxyamphetamine) was considerably less potent [114]. In drug discrimination experiments, complete substitution for LSD and MDMA was found for EDA and IDA, which also correlates in the latter case with [125I]DOI displacement.".
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