Chemistry:Glemanserin

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Short description: Chemical compound
Glemanserin
Glemanserin structure.png
Clinical data
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC20H25NO
Molar mass295.426 g·mol−1
3D model (JSmol)

Glemanserin (INN) (developmental code name MDL-11,939) is a drug which acts as a potent and selective 5-HT2A receptor antagonist.[1] The first truly selective 5-HT2A ligand to be discovered, glemanserin resulted in the development of the widely used and even more potent and selective 5-HT2A receptor antagonist volinanserin (MDL-100,907), which is a fluorinated analogue.[2] Though it was largely superseded in scientific research by volinanserin, glemanserin was investigated clinically for the treatment of generalized anxiety disorder.[3] However, it was ultimately found to be ineffective and was not marketed.[3]

See also

References

  1. ↑ "Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors". Drug Development Research 13 (1): 29–43. 1988. doi:10.1002/ddr.430130104. 
  2. ↑ "5-HT2A, 5-HT2B, and 5-HT2C Receptor Ligands". Serotonin Receptors and Their Ligands. Elsevier. 10 July 1997. p. 167. ISBN 978-0-444-82041-9. https://books.google.com/books?id=lfo0hGqIex0C&pg=PA167. Retrieved 6 May 2012. 
  3. ↑ 3.0 3.1 "Efficacy trial of the 5-HT2 antagonist MDL 11,939 in patients with generalized anxiety disorder". Journal of Clinical Psychopharmacology 15 (1): 20–22. February 1995. doi:10.1097/00004714-199502000-00004. PMID 7714223. 



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