Chemistry:Ro60-0213

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Short description: Chemical compound
Ro60-0213
Ro60-0213.svg
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC15H18N2O
Molar mass242.322 g·mol−1
3D model (JSmol)
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Ro60-0213 (Org 35032) is a drug developed by Hoffmann–La Roche, which acts as a potent and selective agonist for the 5-HT2C serotonin receptor, with more than 100x selectivity over other closely related serotonin receptor subtypes, and little or no affinity at other receptors. It was developed as a potential antidepressant,[1] but was discontinued from clinical development at an early stage due to toxicity concerns.[2] However the high selectivity of Ro60-0213 for 5-HT2C makes it of continued interest for research into serotonin receptors.[3]

See also

References

  1. ↑ "Ligands for the 5-HT2C receptor as potential antidepressants and anxiolytics". Trends in Drug Research II, Proceedings of the 11th Noordwijkerhout-Camerino Symposium. Pharmacochemistry Library. 29. 1998. pp. 49–61. doi:10.1016/S0165-7208(98)80044-5. ISBN 9780444826336. 
  2. ↑ "Suppression of mutagenic activity of a series of 5HT2c receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assay". Mutagenesis 13 (4): 397–403. July 1998. doi:10.1093/mutage/13.4.397. PMID 9717178. 
  3. ↑ "Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists". Bioorganic & Medicinal Chemistry 16 (4): 1966–82. February 2008. doi:10.1016/j.bmc.2007.10.100. PMID 18035544. 



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