Chemistry:LP-211

LP-211
Identifiers
	IUPAC name N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;
CAS Number	1052147-86-0;
PubChem CID	25107716;
ChemSpider	23343345 ;
UNII	NCS2VAH93R;
Chemical and physical data
Formula	C30H34N4O
Molar mass	466.629 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4;
	InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) ; Key:BQEDZLDNNBDKDS-UHFFFAOYSA-N ;
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Short description: Chemical compound

LP-211 is a drug which acts as a potent and selective agonist at the 5HT₇ serotonin receptor, with better brain penetration than older 5-HT₇ agonists in the same series, and similar effects in animals.^[1]^[2]

References

↑ "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters 481 (1): 12–6. August 2010. doi:10.1016/j.neulet.2010.06.036. PMID 20600619.
↑ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.

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Original source: https://en.wikipedia.org/wiki/LP-211. Read more

[pmid20600619-1] "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters 481 (1): 12–6. August 2010. doi:10.1016/j.neulet.2010.06.036. PMID 20600619.

[pmid21459634-2] Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.

[1]

[2]

v t e Piperazines
Simple piperazines (no additional rings)	1-Cyclohexylpiperazine Aminoethylpiperazine Diethylcarbamazine HEPPS Midafotel Piperazine PIPES
Phenylpiperazines	Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin CSP-2503 Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Naphthylpiperazine Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide Piberaline Piribedil Sunifiram Trimetazidine Vesnarinone
Diphenylalkylpiperazines (benzhydrylalkylpiperazines)	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Prazitone Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclics (piperazine attached via side chain)	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/Uncategorized	6-Nitroquipazine Azimilide Cinepazet Cinepazic acid Cinepazide Cyclohexylpiperazine EGIS-7625 Hexocyclium Indinavir JNJ-7777120 Lodenafil Mirodenafil PB-28 Quipazine Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VUF-6002 WY-46824 Zipeprol

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Identifiers

IUPAC name N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
CAS Number	1052147-86-0
PubChem CID	25107716
ChemSpider	23343345^N
UNII	NCS2VAH93R
Chemical and physical data
Formula	C₃₀H₃₄N₄O
Molar mass	466.629 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4
InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)^N Key:BQEDZLDNNBDKDS-UHFFFAOYSA-N^N
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