Chemistry:ORG-37684

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ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, including of the serotonin 5-HT2C, 5-HT2B, and 5-HT2A receptors, in that order of potency.[1][2][3] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[4] ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans.[1] The drug was under development for the treatment of major depressive disorder in the 1990s and early 2000s, and reached the preclinical research stage, but development was discontinued and it was never marketed.[5][6]

See also

References

  1. ↑ 1.0 1.1 "Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists". Pharmacol Biochem Behav 69 (3–4): 643–652. 2001. doi:10.1016/s0091-3057(01)00552-4. PMID 11509227. 
  2. ↑ "Efficient Synthesis of the 5-Ht2C Receptor Agonist, Org 37684". Synthetic Communications 31 (13): 2029–2036. 2001. doi:10.1081/SCC-100104420. 
  3. ↑ "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 370 (2): 114–23. August 2004. doi:10.1007/s00210-004-0951-4. PMID 15322733. 
  4. ↑ "Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat". Progress in Neuro-Psychopharmacology & Biological Psychiatry 26 (3): 441–9. April 2002. doi:10.1016/s0278-5846(01)00284-6. PMID 11999893. 
  5. ↑ "ORG 37684". 22 January 2007. https://adisinsight.springer.com/drugs/800009204. 
  6. ↑ "Delving into the Latest Updates on Org-37684 with Synapse". 24 January 2026. https://synapse.patsnap.com/drug/e2c888766bfc4b3c8222b486f4cd6ddd. 



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