Chemistry:Pirenperone

Short description: Chemical compound

Pirenperone

Clinical data
Other names	R-47456; R-50656
Identifiers
IUPAC name 3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one
CAS Number	75444-65-4
PubChem CID	4847
ChemSpider	4681
UNII	Y9FMC4513X
KEGG	D05495
ChEBI	CHEBI:92444
ChEMBL	ChEMBL18331
Chemical and physical data
Formula	C23H24FN3O2
Molar mass	393.462 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F
InChI InChI=1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3 Key:HXCNRYXBZNHDNE-UHFFFAOYSA-N

Pirenperone (INN, USAN, BAN; developmental code names R-47456, R-50656) is a serotonin receptor antagonist described as an antipsychotic and tranquilizer which was never marketed. It is a relatively selective antagonist of the serotonin 5-HT₂ receptors and has been used in scientific research to study the serotonin system. In the 1980s, the drug was found to block the effects of the lysergic acid diethylamide (LSD) in animals, and along with ketanserin, led to the elucidation of the 5-HT_2A receptor as the biological mediator of the effects of serotonergic psychedelics.

See also

• Altanserin
• Ketanserin
• Setoperone
• Risperidone
• Ocaperidone