Chemistry:UH-301

From HandWiki
Short description: Chemical compound
UH-301
Skeletal formula of UH-301
Space-filling model of the UH-301 molecule
Identifiers
CAS Number
IUPHAR/BPS
UNII
Chemical and physical data
FormulaC16H24FNO
Molar mass265.372 g·mol−1
3D model (JSmol)
  (verify)

(S)-UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1A receptor silent antagonist.[1] It is structurally related to 8-OH-DPAT.[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.[2]

See also

References

  1. ↑ 1.0 1.1 "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". The Journal of Pharmacology and Experimental Therapeutics 258 (1): 58–65. July 1991. PMID 1830099. 
  2. ↑ "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior 55 (1): 1–10. September 1996. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:UH-301&oldid=2984684"