Chemistry:SB-204070

SB-204070
Identifiers
	IUPAC name (1-butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate;
CAS Number	148688-01-1 ;
PubChem CID	121881;
IUPHAR/BPS	256;
ChemSpider	108731;
UNII	DQ39GL43SF;
ChEMBL	ChEMBL68131;
Chemical and physical data
Formula	C19H27ClN2O4
Molar mass	382.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Nc1c2OCCOc2c(cc1Cl)C(=O)OCC3CCN(CCCC)CC3;
	InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3; Key:AOOSJYIINXVNHV-UHFFFAOYSA-N;

Short description: Chemical compound

SB-204070 is a drug which acts as a potent and selective 5-HT₄ serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.^[1]^[2]^[3]^[4]^[5]

References

↑ "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology 131 (4): 827–35. October 2000. doi:10.1038/sj.bjp.0703641. PMID 11030734.
↑ "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology 61 (1): 85–96. January 2002. doi:10.1124/mol.61.1.85. PMID 11752209.
↑ "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus 12 (3): 304–10. 2002. doi:10.1002/hipo.10012. PMID 12099482.
↑ "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research 973 (1): 92–8. May 2003. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957.
↑ "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". FASEB Journal 20 (14): 2486–95. December 2006. doi:10.1096/fj.06-6391com. PMID 17142798.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/SB-204070. Read more

[pmid11030734-1] "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology 131 (4): 827–35. October 2000. doi:10.1038/sj.bjp.0703641. PMID 11030734.

[pmid11752209-2] "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology 61 (1): 85–96. January 2002. doi:10.1124/mol.61.1.85. PMID 11752209.

[pmid12099482-3] "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus 12 (3): 304–10. 2002. doi:10.1002/hipo.10012. PMID 12099482.

[pmid12729957-4] "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research 973 (1): 92–8. May 2003. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957.

[pmid17142798-5] "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". FASEB Journal 20 (14): 2486–95. December 2006. doi:10.1096/fj.06-6391com. PMID 17142798.

[1]

[2]

[3]

[4]

[5]

Anonymous

Search

Chemistry:SB-204070

Namespaces

More

Page actions

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Identifiers

IUPAC name (1-butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate
CAS Number	148688-01-1^Y
PubChem CID	121881
IUPHAR/BPS	256
ChemSpider	108731
UNII	DQ39GL43SF
ChEMBL	ChEMBL68131
Chemical and physical data
Formula	C₁₉H₂₇ClN₂O₄
Molar mass	382.89 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Nc1c2OCCOc2c(cc1Cl)C(=O)OCC3CCN(CCCC)CC3
InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 Key:AOOSJYIINXVNHV-UHFFFAOYSA-N

Anonymous

Search

Chemistry:SB-204070

References

Navigation

Wiki tools

Page tools

Other projects

Categories