Chemistry:Bay R 1531

From HandWiki
Short description: Chemical compound
Bay R 1531
Clinical data
Other namesLY-197206; LY197206
Drug classSerotonin 5-HT1A receptor agonist; Simplified/partial LSD analogue
Identifiers
CAS Number
PubChem CID
PubChem SID
ChemSpider
Chemical and physical data
FormulaC18H26N2O
Molar mass286.419 g·mol−1
3D model (JSmol)

Bay R 1531, also known as LY-197206, is a tricyclic tryptamine derivative. It acts as a selective serotonin 5-HT1A receptor agonist. It was investigated unsuccessfully for the treatment of stroke but continues to be used in scientific research.[1][2][3][4] It shows very high affinity for the serotonin 5-HT1A receptor (Ki = 1.3 nM).[5][6]

See also

References

  1. ↑ "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke 21 (12 Suppl): IV161-3. December 1990. PMID 2148035. 
  2. ↑ "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology 106 (4): 484–90. 1992. doi:10.1007/bf02244819. PMID 1533721. 
  3. ↑ "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior 56 (3): 481–6. March 1997. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586. 
  4. ↑ "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology 345 (3): 253–6. March 1998. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023. 
  5. ↑ "Structure-activity relationships at 5-HT1A receptors: binding profiles and intrinsic activity". Pharmacol Biochem Behav 40 (4): 1041–1051. December 1991. doi:10.1016/0091-3057(91)90124-k. PMID 1816558. 
  6. ↑ "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sci 41 (16): 1961–1969. October 1987. doi:10.1016/0024-3205(87)90749-1. PMID 3657392. https://www.thevespiary.org/rhodium/Rhodium/Vespiary/talk/files/5370-Relative-selectivity-of-some-conformationally-constrained-tryptamine-analogs-at-5-HT1-5-HT1A-and-5-HT2-recognition-sites3db1.pdf. Retrieved 2025-03-24. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Bay_R_1531&oldid=4037141"