Chemistry:Bay R 1531

Bay R 1531
Identifiers
	IUPAC name 1,3,4,5-tetrahydro-6-methoxy-N,N-dipropyl-benz[cd]indol-4-amine;
CAS Number	98770-54-8;
PubChem CID	127153;
ChemSpider	112872;
Chemical and physical data
Formula	C18H26N2O
Molar mass	286.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc2ccc1[nH]cc3CC(Cc2c13)N(CCC)CCC;
	InChI InChI=1S/C18H26N2O/c1-4-8-20(9-5-2)14-10-13-12-19-16-6-7-17(21-3)15(11-14)18(13)16/h6-7,12,14,19H,4-5,8-11H2,1-3H3; Key:BMZWFSGTPJUKJR-UHFFFAOYSA-N;

Short description: Chemical compound

Bay R 1531 is a tricyclic tryptamine derivative which acts as a selective serotonin receptor 5-HT_1A agonist. It was researched unsuccessfully for the treatment of stroke but remains in use for scientific research.^[1]^[2]^[3]^[4]

References

↑ "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke 21 (12 Suppl): IV161-3. December 1990. PMID 2148035.
↑ "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology 106 (4): 484–90. 1992. doi:10.1007/bf02244819. PMID 1533721.
↑ "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior 56 (3): 481–6. March 1997. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586.
↑ "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology 345 (3): 253–6. March 1998. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023.

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[1] "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke 21 (12 Suppl): IV161-3. December 1990. PMID 2148035.

[2] "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology 106 (4): 484–90. 1992. doi:10.1007/bf02244819. PMID 1533721.

[3] "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior 56 (3): 481–6. March 1997. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586.

[4] "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology 345 (3): 253–6. March 1998. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023.

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Identifiers

IUPAC name 1,3,4,5-tetrahydro-6-methoxy-N,N-dipropyl-benz[cd]indol-4-amine
CAS Number	98770-54-8
PubChem CID	127153
ChemSpider	112872
Chemical and physical data
Formula	C₁₈H₂₆N₂O
Molar mass	286.419 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc2ccc1[nH]cc3CC(Cc2c13)N(CCC)CCC
InChI InChI=1S/C18H26N2O/c1-4-8-20(9-5-2)14-10-13-12-19-16-6-7-17(21-3)15(11-14)18(13)16/h6-7,12,14,19H,4-5,8-11H2,1-3H3 Key:BMZWFSGTPJUKJR-UHFFFAOYSA-N

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